Dosage and administration in metastatic breast cancer
In the metastatic setting, Herceptin should be administered once a week as an intravenous infusion until disease progression.
Table 3.3 Recommended dosing instructions for Herceptin
To administer Herceptin, each 150 mg vial should be reconstituted with 7.2 mL sterile water for injection, swirling rather than shaking to avoid foaming. Reconstitution yields a single-dose solution containing approximately 21 mg/mL Herceptin. The volume of reconstituted Herceptin required for dosing should be calculated according to patient body weight as follows:
| Volume (mL) = |
Body weight (kg) x required concentration (mg/kg) 21 (mg/mL [concentration of reconstituted solution]) |
The appropriate amount of Herceptin solution should be added to an infusion bag containing 250 mL 0.9% sodium chloride, inverting the solution to mix in order to avoid foaming. Herceptin should not be administered as an intravenous push or bolus.
For further information on Herceptin administration and dosing see the
European Summary of Product Characteristics.